cliffordfosterr
584 posts
Jun 13, 2025
11:39 PM
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Malegra 100, which contains sildenafil citrate as its active ingredient, is primarily metabolized in the liver through the cytochrome P450 enzyme system. The Malegra 100 mg main enzyme responsible for its metabolism is CYP3A4, with a minor contribution from CYP2C9. After oral administration, sildenafil is rapidly absorbed and undergoes extensive first-pass metabolism.
CYP3A4 catalyzes the N-demethylation of sildenafil to its major circulating metabolite, N-desmethylsildenafil, which possesses approximately 50% of the pharmacologic activity of the parent compound. Though this metabolite contributes to the drug’s overall effect, its plasma levels are only about 40% of sildenafil's, resulting in a modest impact on efficacy. CYP2C9 contributes to a lesser extent by hydroxylating sildenafil at different positions.
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