Yes, Malegra 25, which contains sildenafil citrate, requires sexual stimulation to work effectively. Here’s why:

Mechanism of Action: Sildenafil citrate, the active ingredient in Malegra 25 mg, works by inhibiting the enzyme phosphodiesterase type 5 (PDE5). This inhibition leads to increased levels of cyclic guanosine monophosphate (cGMP), which helps relax the blood vessels in the penis and allows increased blood flow during sexual arousal.

Role of Sexual Stimulation: Sexual stimulation is necessary to initiate the release of nitric oxide (NO) in the penile tissues. Nitric oxide activates the production of cGMP, which is essential for the vasodilation and increased blood flow needed to achieve and maintain an erection. Without sexual arousal, the biochemical processes that lead to an erection do not occur, and sildenafil cannot exert its effect.

Effective Use: To achieve the desired results with Malegra 25, it should be taken approximately 30 minutes to an hour before anticipated sexual activity. The medication does not cause an erection on its own; it facilitates the natural erectile response to sexual stimulation.