machia
86 posts
Feb 20, 2024
12:32 AM
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Vidalista Black 80 mg, like other medications containing tadalafil, is used to treat erectile dysfunction (ED) in men. It works by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which plays a role in regulating blood flow to the penis.
Here's how Vidalista Black 80 mg works in treating erectile dysfunction:
Enhancement of Nitric Oxide (NO) Release: Sexual stimulation triggers the release of nitric oxide (NO) in the erectile tissue of the penis. Nitric oxide activates an enzyme called guanylate cyclase, which leads to increased levels of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the penis.
Relaxation of Smooth Muscle Cells: Increased levels of cGMP cause the smooth muscle cells in the walls of the penile arteries to relax. This relaxation allows blood to flow into the penis, leading to an erection. However, the enzyme phosphodiesterase type 5 (PDE5) breaks down cGMP, limiting its effects on smooth muscle relaxation and blood flow.
Inhibition of PDE5: Vidalista Black 80mg contains tadalafil, which is a PDE5 inhibitor. Tadalafil works by blocking the action of PDE5, thereby preventing the breakdown of cGMP and allowing it to accumulate in the smooth muscle cells of the penis for a longer period. This prolonged presence of cGMP promotes continued relaxation of the smooth muscle cells and sustained blood flow into the penis, which helps to achieve and maintain an erection sufficient for sexual activity.
Duration of Action: Tadalafil has a longer duration of action compared to other PDE5 inhibitors, such as sildenafil and vardenafil. This allows for a longer window of opportunity for sexual activity, with some individuals experiencing the effects of Vidalista Black 80 mg for up to 36 hours after dosing. This feature has earned tadalafil the nickname "the weekend pill."
In summary, Vidalista Black 80 mg works by inhibiting PDE5, which leads to increased levels of cGMP in the smooth muscle cells of the penis, relaxation of the penile arteries, and improved blood flow, ultimately resulting in the ability to achieve and maintain an erection during sexual stimulation.
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